Figure 2.

Modeling adipogenesis: (A) cell culture models used to study adipogenesis in vitro. Although 2D cell culture models are simple and reproducible, they lack the complexity and physiological relevance exhibited in 3D cell culture models. Example of complex 3D cell culture models, (B) using 3D collagen matrices as a biomimetic tissue model and (C) a white adipose tissue (WAT)-on-a-chip. Images are adapted with permission from References [99,100], for Figure 2B and 2C, respectively.