Figure 1.

Mice with deletions in Lmna and Emd, including those with total germline deficiencies of both, are born at expected Mendelian ratios. (A) Offspring of crosses between Lmna^+/−;Emd^−/− and Lmna^+/−;Emd^−/y mice (see Supplementary Material, Fig. S1A). Top: numbers of mice born, actual ratios and expected ratios for male mice that were Lmna^+/+, Lmna^+/− or Lmna^−/− combined with hemizygous deletion of Emd (Emd^−/y). Bottom: numbers of mice born, actual ratios and expected ratios for female mice that were Lmna^+/+, Lmna^+/− or Lmna^−/− combined with homozygous deletion of Emd (Emd^−/−). χ² and P-value for goodness of fit determination are shown in a rectangular box at the bottom of the results of male and female offspring. Standard χ² value at α = 0.05 with 2 degrees of freedom is 5.991, which is higher than the calculated χ² values. (B) Offspring of crosses between Lmna^+/−;Emd^+/+ and Lmna^+/−;Emd^+/y mice (see Supplementary Material, Fig. S1B). Top: numbers of mice born, actual ratios and expected ratios for male mice that were Lmna^+/+, Lmna^+/− or Lmna^−/− with normal Emd (Emd^+/y). Bottom: numbers of mice born, actual ratios and expected ratios for female mice that were Lmna^+/+, Lmna^+/− or Lmna^−/− with normal Emd (Emd^+/+). χ² and P-value for goodness of fit determination are shown in a rectangular box at the bottom of the results for male and female offspring. Standard χ² value at α = 0.05 with 2 degrees of freedom is 5.991, which is higher than the calculated χ² values.