FIGURE 3.

Targets for sdAbs in the coagulation and fibrinolysis pathways. An overview of the major activation and inactivation reactions in the coagulation and fibrinolysis pathway are shown. Red circles indicate sdAbs and their targets that have been mentioned in this review. APC, activated Protein C; α2AP, α2‐antiplasmin; AT, antithrombin; F, factor; Plm, plasmin; Plg, plasminogen; PAI‐1, plasminogen activator inhibitor‐1; PC, protein C; PN1, Protease nexin‐1; ProtS, protein S; ProtZ, protein Z; TAFI, thrombin‐activatable fibrinolysis inhibitor; TM, thrombomodulin; TF, tissue factor; TFPI, tissue factor pathway inhibitor; t‐PA, tissue‐type plasminogen activator; u‐PA, urokinase plasminogen activator; VWF, von Willebrand factor; ZPI, protein Z–dependent protease inhibitor