Figure 4.

Mean profiles of FIX activity in prophylaxis. FIX, coagulation factor IX. Points are means; error bars represent standard error of means. The analysis is based on a mixed model on the log‐transformed plasma concentrations with patient as a random effect. The mean FIX activity level is presented back‐transformed to the natural scale. Only patients with a minimum of 4 weeks of prophylaxis were included. Measurements (n = 188) must have been taken ≥ 5 days and ≤ 10 days after the last dose. Measurements associated with doses within ≥ 14 days after a bleed were not included in the analysis. FIX activity up to 196 exposure days is reported