FIGURE 6.

Schematic representation of tyrosyl‐tRNA synthetase (YRS) cleavage, storage in platelets, and potential function to activate monocytes. Circulating YRS can be cleaved by elastase or matrix metalloproteinases (MMPs) in plasma, producing a constitutively active form of YRS. YRS^WT and its cleaved forms, YRS^Mini and YRS^Mini+, can be taken up by platelets, mediated by integrins or other receptors, and then partially stored in α‐granules where they are protected from further degradation. Upon activation, platelets may release the stored YRS, thereby activating monocytes/macrophages. Monocyte activation leads to MMP upregulation which may enhance YRS cleavage, producing more active YRS and feed‐forward loop