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ROCK in renal health and disease.
Rho/ROCK signaling executes control of the cell shape, proliferation, and gene expression via cytoskeletal rearrangement. From a pathological perspective, renal ROCK signaling is activated by glucose and cytokines in the context of diabetes. The effects of the elevated ROCK activity manifest as the progression of mesangial expansion and podocyte loss, establishing a critical role for ROCK in DKD.
