Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
ROCK-dependent transcriptional regulation during the progression of DKD.
A parallel mechanism operates in the diabetic kidney via hypoxia-dependent fibrotic responses and tissue damage elicited by inflammation. ROCK governs two important transcription factors in this framework, hypoxia-inducible factor 1α (HIF-1α) and nuclear factor κB (NF-κB). The molecular basis for these effects involves the inhibition of proteasomal degradation of HIF-1α and promotion of NF-κB nuclear transport.
