Table 5.

Currently available drugs for PsA [89]

Drug	Mechanism
Nonsteroidal anti-inflammatory drugs (NSAIDs)	Anti-inflammatory
Corticosteroids	Anti-cortisol / Anti-inflammatory
Methotrexate	Inhibition of purine metabolism – inhibition of T-cell activation
Sulfasalazine	Immunosuppressive
Cyclosporine	T-cell suppressant / calcineurin–phosphatase pathway inhibition
Leflunomide	pyrimidine synthesis inhibitor / slows rapidly replicating lymphocytes
Etanercept, adalimumab, golimumab, infliximab and certolizumab	TNF alpha inhibitors
Abatacept	B7 protein inhibitor(antagonist) / blocks activation of T-cells
Ustekinumab	IL-12 and IL-23 inhibitor