Table 3.

Univariate and multivariate analysis for radiation necrosis

Covariate	HR (95% CI)	P-value
Univariate
Surgical resection	1.92 (0.57–6.46)	0.29
Tumor size ≤2 cm	0.28 (0.13–0.63)	0.002
Concurrent systemic therapy	1.03 (0.41–2.59)	0.94
Location of metastasis	1.23 (0.46–3.29)	0.68
Single vs Multi-fraction SRT	1.24 (0.52–2.96)	0.64
Age	0.99 (0.95–1.02)	0.47
Recent Immunotherapy	0.50 (0.17–1.45)	0.20
Prior WBRT	1.89 (0.86–4.15)	0.11
Multivariate
Recent immunotherapy	0.98 (0.28–3.51)	0.98
Prior WBRT	1.55 (0.56–4.31)	0.40
Tumor size ≤2 cm	0.24 (0.09–0.64)	0.004