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. 2020 Oct 27;13:158. doi: 10.1186/s12920-020-00812-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The genetic alterations and methylation level of NEK2, NDC80 and CEP250 in HCC. a The genetic alterations of NEK2, NDC80 and CEP250 in HCC. The queried genes (NEK2, NDC80, CEP250) were altered in 111/366 (30%) of queried samples. The genetic alteration frequencies of NEK2, NDC80 and CEP250 were 19%, 7% and 14%, respectively. The detailed genetic alteration types included Amplification, Missense Mutation, Truncating Mutation and mRNA High. b The methylation level of NEK2, NDC80 and CEP250 in HCC. Red represents high methylation level, and blue represents low methylation level