Table 1.
The main GO and KEGG pathways involving NEK2 and its interacting proteins downloaded from STRING database
| Categories | Pathway ID | Pathway description | Gene count | FDR | Genes |
|---|---|---|---|---|---|
| Biological process (GO) | GO:0007049 | Cell cycle | 7 | 2.78E-05 | CEP250,MAD1L1,MAPK1,NDC80,NEK11,NEK2,PPP1CA |
| GO:1901990 | Regulation of mitotic cell cycle phase transition | 5 | 4.01E-05 | CEP250,MAD1L1,NDC80,NEK11,NEK2 | |
| GO:1903047 | Mitotic cell cycle process | 5 | 0.00021 | CEP250,MAD1L1,NDC80,NEK11,NEK2 | |
| Molecular function (GO) | GO:0019902 | Phosphatase binding | 3 | 0.0026 | MAPK1,NEK2,PPP1CA |
| GO:0004674 | Protein serine/threonine kinase activity | 3 | 0.0219 | MAPK1,NEK11,NEK2 | |
| GO:0019903 | Protein phosphatase binding | 2 | 0.0265 | NEK2,PPP1CA | |
| Cellular component (GO) | GO:0005815 | Microtubule organizing center | 5 | 0.00037 | CEP250,MAD1L1,MAPK1,NDC80,NEK2 |
| GO:0005813 | Centrosome | 4 | 0.00059 | CEP250,MAD1L1,NDC80,NEK2 | |
| GO:0000777 | Condensed chromosome kinetochore | 3 | 0.00059 | MAD1L1,NDC80,NEK2 | |
| KEGG pathways | hsa04720 | Long-term potentiation | 2 | 0.0337 | MAPK1,PPP1CA |
| hsa04914 | Progesterone-mediated oocyte maturation | 2 | 0.0356 | MAD1L1,MAPK1 | |
| hsa04022 | cGMP-PKG signaling pathway | 2 | 0.0358 | MAPK1,PPP1CA |
FDR false discovery rate