Table 2.
The main GO and KEGG pathways associated with NEK2 and its interacting proteins by DAVID and KOBAS 3.0 databases analyses
| Categories | Pathway ID | Pathway description | Gene count | p-value | Genes |
|---|---|---|---|---|---|
| Biological process (GO) | GO:0006793 | Phosphorus metabolic process | 4 | 0.0015 | MAPK1, PPP1CA, NEK2, NEK11 |
| GO:0006796 | Phosphate metabolic process | 4 | 0.0015 | MAPK1, PPP1CA, NEK2, NEK11 | |
| GO:0007049 | Cell Cycle | 3 | 0.00507 | MAPK1, PPP1CA, NEK2 | |
| Molecular function (GO) | GO:0004674 | Protein serine/threonine kinase activity | 3 | 0.00526 | MAPK1, NEK2, NEK11 |
| KEGG pathways | hsa04720 | Long-term potentiation | 2 | 0.00015 | MAPK1, PPP1CA |
| hsa04114 | Oocyte meiosis | 2 | 0.00048 | MAPK1, PPP1CA | |
| hsa04270 | Vascular smooth muscle contraction | 2 | 0.00051 | MAPK1, PPP1CA | |
| hsa04611 | Platelet activation | 2 | 0.00052 | MAPK1, PPP1CA | |
| hsa04910 | Insulin signaling pathway | 2 | 0.00066 | MAPK1, PPP1CA |