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. 2020 Oct 27;22:113. doi: 10.1186/s13058-020-01351-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — KYNU enzyme expression and activity in HC and various BrCa subtypes. a KYNU mRNA expression level is most significantly increased in HER2-enriched BrCa patient tumor tissues from the METABRIC dataset. b KYNU protein immunohistochemistry in BrCa tissues shows that KYNU expression is highest in the TN BrCa subtype. Representative images of KYNU staining in BrCa tumor tissue subtypes are shown with semi-quantification (n = 10 each subtype; scale bar, 1000 μM)