Table 3. Performance of the InterVA (Interpreting Verbal Autopsy) model at individual-level prediction among all cases who died of infectious diseases according to the complete diagnostic autopsy.
| Cause of death (CDA) | n | Classification of cases | Sensitivity
(%) |
Specificity
(%) |
PPV
(%) |
NPV
(%) |
|||
|---|---|---|---|---|---|---|---|---|---|
| TP | TN | FP | FN | ||||||
| Disseminated infections | 51 | 0 | 139 | 2 | 51 | 0 | 99 | 0 | 73 |
| Pneumonia | 36 | 13 | 102 | 54 | 23 | 36 | 65 | 19 | 82 |
| Meningitis | 15 | 3 | 173 | 4 | 12 | 20 | 98 | 43 | 94 |
| Tuberculosis | 7 | 0 | 183 | 2 | 7 | 0 | 99 | 0 | 96 |
| Diarrhoea | 2 | 0 | 186 | 4 | 2 | 0 | 98 | 0 | 99 |
| HIV/AIDS related | 57 | 18 | 120 | 15 | 39 | 32 | 89 | 55 | 75 |
| Malaria | 6 | 2 | 181 | 5 | 4 | 33 | 97 | 29 | 98 |
| Other infections | 18 | 0 | 171 | 3 | 18 | 0 | 98 | 0 | 90 |
CDA: complete diagnostic autopsy; n: number of cases; TP: true positives; TN: true negatives; FP: false positives; FN: false negatives; PPV: positive predictive value; NPV: negative predictive value; N/A: not applicable
Disseminated infections: bacterial sepsis of newborn (n=21), puerperal sepsis (n=6), streptococcal sepsis (n=5) and other sepsis (n=19)
HIV/AIDS related infections: candidiasis (n=1), congenital viral diseases (n=1), cryptococcosis (n=11), cytomegaloviral disease (n=7), herpes simplex infection (n=1), miliary tuberculosis (n=20), salmonella infections (n=1), pneumocystosis (n=5), pulmonary tuberculosis (n=2), toxoplasmosis (n=7) and tuberculous meningitis (n=1)
Other infections: acute pericarditis (n=2), pyelonephritis (n=2), congenital viral diseases (n=2), chorioamnionitis (n=2), GBS infection (n=2), tetanus (n=1), peritonitis (n=3), rabies (n=3) and zygomycosis (n=1)