Table 4. Cause-Specific Mortality Fractions and associated measures of validation of the InterVA (Interpreting Verbal Autopsy) model compared with the complete diagnostic autopsy (CDA) at the population level.
| Group | Cause of death | InterVA | CDA | CSMF Accuracy | |||
|---|---|---|---|---|---|---|---|
| n* | CSMF (%) | n | CSMF (%) | Uncorrected | Chance
Corrected |
||
| Stillbirths | Infections | 0 | 0.0 | 4 | 22.2 | 0.11 | -1.00 |
| Fetal growth restriction | 1 | 5.0 | 7 | 38.9 | |||
| Intrapartum hypoxia | 0 | 0.0 | 3 | 16.7 | |||
| Intrauterine hypoxia | 0 | 0.0 | 2 | 11.1 | |||
| Congenital malformations | 7 | 38.9 | 0 | 0.0 | |||
| Non conclusive | 10 | 56.1 | 2 | 11.1 | |||
| Overall | 18 | 100.0 | 18 | 100.0 | |||
| Neonates | Infections | 37 | 91.0 | 27 | 65.9 | 0.73 | 0.50 |
| Congenital malformations | 1 | 2.4 | 4 | 9.8 | |||
| Preterm complications | 0 | 0.0 | 5 | 12.2 | |||
| Intrapartum complications | 2 | 4.5 | 3 | 7.3 | |||
| Other diseases | 0 | 0.0 | 2 | 4.9 | |||
| Non-conclusive | 1 | 2.1 | 0 | 0.0 | |||
| Overall | 41 | 100.0 | 41 | 100.0 | |||
| Children | Infections | 40 | 73.9 | 42 | 77.8 | 0.77 | 0.62 |
| Congenital malformations | 0 | 0.0 | 2 | 3.7 | |||
| Malignant neoplasms | 0 | 0.0 | 7 | 13.0 | |||
| Other diseases | 7 | 13.7 | 3 | 5.6 | |||
| Non-conclusive | 7 | 12.5 | 0 | 0.0 | |||
| Overall | 54 | 100.0 | 54 | 100.0 | |||
| Maternal deaths | Infections * | 22 | 24.1 | 39 | 42.9 | 0.59 | -0.05 |
| Abortion | 0 | 0.0 | 9 | 9.9 | |||
| Eclampsia | 25 | 27.5 | 4 | 4.4 | |||
| Obstetric hemorrhage | 26 | 28.1 | 16 | 17.6 | |||
| Other obstetric
complications |
0 | 0.4 | 6 | 6.6 | |||
| Non-obstetric diseases ** | 11 | 12.0 | 16 | 17.6 | |||
| Non-conclusive | 7 | 7.9 | 1 | 1.1 | |||
| Overall | 91 | 100.0 | 91 | 100.0 | |||
| Other adults | Infections | 65 | 58.2 | 80 | 71.4 | 0.76 | 0.49 |
| Malignant neoplasms | 4 | 3.7 | 16 | 14.3 | |||
| Other diseases | 33 | 29.8 | 16 | 14.3 | |||
| Non-conclusive | 9 | 8.4 | 0 | 0.0 | |||
| Overall | 112 | 100.0 | 112 | 100.0 | |||
CDA: Complete diagnostic autopsy; n*: sum of cases estimated by InterVA model (in cause 1 or 2) weighted by their associated likelihood. The residual likelihoods count as non-conclusive case fractions; n: sum of cases established by the CDA; CSMF: cause-specific mortality fractions; CSMF Accuracy:measures the quality at the population level, quantifying how closely the estimated CSMF values approximate the truth; Uncorrected: median cause-specific mortality fractions accuracy across 500 Dirichlet draws. It ranges from zero to one; Chance corrected: Median Cause-Specific Mortality Fractions Accuracy for random allocation across 500 Dirichlet draws. A score of zero indicates predictive accuracy equal to random allocation.
* Includes all infections, both obstetric and non-obstetric.
** Non-obstetric diseases do not include infections.