Fig. 1.

Aged males experience higher mortality and hemorrhagic transformation rates than females despite no difference in infarct size. A) Percent infarcted brain area in cortex, striatum and hemisphere 3 days post-stroke measured on 2,3,5-triphenyltetrazolium chloride (TTC) stained brain sections, n=5-6. B) Kaplan Meier survival analysis demonstrate significantly higher mortality in males vs females, Log-rank (Mantel-Cox) test p<0.05, n=44-47. C) Representative TTC images of male (4 days post-stroke) and female (1 day post-stroke) mortality cases. Hemorrhagic transformation (depicted with arrow heads) were found in 44% of the males and in 0% of the females that died.