Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 26;218(2):e20191054. doi: 10.1084/jem.20191054

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Wang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 5. — AdipoRon administration suppresses ILC2 and energy expenditure in adiponectin KO mice. (A) The effect of AdipoRon administration (30 mg/kg i.p. once per day for 5 d) on basal and cold-induced O₂ consumption in 10-wk-old adiponectin KO mice. 24 h after administration of AdipoRon, the calorimetry study was performed. The average O₂ consumption was normalized to whole-body mass and analyzed by ANOVA. n = 7–9/group. Data are presented as means ± SEM. *, P < 0.05. (B and C) Expression levels of UCP1, C/EBPβ, and PGC1α were significantly down-regulated by AdipoRon administration in iWAT (B) without significant difference in BAT (C) in adiponectin KO mice. Representative data are presented. (D and E) Administration of AdipoRon decreased the fractions of ILC2s (D) and M2 macrophages (E) in iWAT in adiponectin KO mice despite no significance in eWAT. n = 4–6/group. Data are presented as means ± SEM. *, P < 0.05, Student’s t test. (F) Intra-iWAT injection of AdipoRon (3 mg/kg body mass) suppressed cold-induced expression of UCP1, C/EBPβ, and PGC1α in iWAT. Representative data are presented. (G) The data in F were quantified and analyzed. n = 5–7/group. Data are presented as means ± SEM. *, P < 0.05; **, P < 0.01; Student’s t test. A, AdipoRon; V and Veh, vehicle.