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. 2020 Oct 27;20:520. doi: 10.1186/s12935-020-01607-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cell cycle of BCa cells was arrested in G0/G1 phase by plumbagin treatment. a, b Representative FACS images of cell cycle with plumbagin treatment in T24 and UMUC3 cells, respectively, and quantitative analysis of cell cycle proportions showed a remarkable increase in G0/G1 phase cells; c, d The relative mRNA expression of MDM2, GADD, p53, CDK2, CDK4, p21 and CDK6 could be modulated when T24 and UMUC3 cells were treated with plumbagin at 0, 0.75, 1.5 μM; e The expression levels of CDK2, CDK4, CDK6, CCND1, CCNE1, CCNB1, p53, p27, p21 were determined by western blotting assay. GAPDH was as the internal control. **P < 0.01, ***P < 0.001