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. 2020 Oct 27;20:520. doi: 10.1186/s12935-020-01607-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Plumbagin suppressed BCa tumorigenesis in vivo. a, b The photographs of tumor bearing mice and dissected tumor samples, respectively; c The HE staining images of tumor samples, a1-3 and b1-3 corresponding to the three individual animals in the PL group and B.C groups, respectively. Scale Bar: 100 μm; d the growth curves of animal weight during the whole period of drug injection; e the growth curves of tumor volume; f quantitative results of tumor weight; g representative HE staining images of the main organs (heart, liver, spleen, lung and kidney) dissected from the treated mice; h representative Masson staining images of the main organs. Scale Bar: 100 μm. *P < 0.05, **P < 0.01, and ***P < 0.001