Table 3.

gBRCAm prevalence by risk factors for gBRCAm (FAS)

Risk factor	Positive for a gBRCAm, n (% [95% CI])	gBRCA1m only, n (% [95% CI])	gBRCA2m only, n (% [95% CI])	Both gBRCA1m and gBRCA2m, n (% [95% CI])
Age at initial breast cancer diagnosis
≤ 50 years (N = 171)	22 (12.9 [8.2, 18.8])	13 (7.6 [4.1, 12.6])	6 (3.5 [1.3, 7.5])	3 (1.8 [0.4, 5.0])
> 50 years (N = 167)	9 (5.4 [2.5, 10.0])	2 (1.2 [0.1, 4.3])	5 (3.0 [1.0, 6.8])	2 (1.2 [0.1, 4.3])
HR status
HR-positive (N = 215)	20 (9.3 [5.8, 14.0])	6 (2.8 [1.0, 6.0])	10 (4.7 [2.3, 8.4])	4 (1.9 [0.5, 4.7])
HR-negative (N = 119)	11 (9.2 [4.7, 15.9])	9 (7.6 [3.5, 13.9])	2 (1.7 [0.2, 5.9])	0 (0.0 [0.0, 3.1])
Family history of breast and/or ovarian cancer
Yes (N = 66)	15 (22.7 [13.3, 34.7])	8 (12.1 [5.4, 22.5])	6 (9.1 [3.4, 18.7])	1 (1.5 [0.0, 8.2])
No (N= 274)	18 (6.6 [3.9, 10.2])	8 (2.9 [1.3, 5.7])	6 (2.2 [0.8, 4.7])	4 (1.5 [0.4, 3.7])

BRCA breast cancer susceptibility gene, CI confidence interval, FAS full analysis set, gBRCAm germline BRCA mutation, HR hormone receptor