Table 2.
The diagnostic assessment of the different commercial IgG ELISA kits according to time of sample collection after symptoms onset.
| Days after symptoms onset | ELISA kit | Sensitivity % (95% CI) |
Positive predictive value % (95% CI) |
Negative predictive value % (95% CI) |
Positive percent agreement % (95% CI) |
Cohen's kappa k (95% CI) |
|---|---|---|---|---|---|---|
| ≤7 days (n = 28) | EDI | 57.1 (39.1–73.5) | 88.9 (67.2–96.9) | 85.0 (75.6–91.2) | 85.7 (77.4–91.3) | 0.61 (0.49–0.72) |
| AnshLabs | 78.6 (60.5–89.8) | 56.4 (41.0–70.7) | 89.8 (79.5–95.3) | 76.5 (67.2–83.8) | 0.49 (0.36–0.61) | |
| Dia.Pro | 57.1 (39.1–73.5) | 88.9 (67.2–96.9) | 85.0 (75.6–91.2) | 85.7 (77.4–91.3) | 0.61 (0.49–0.72) | |
| NovaTec | 64.3 (45.8–79.3) | 64.3 (45.8–79.3) | 85.7 (75.7–92.1) | 79.6 (70.6–86.4) | 0.50 (0.38–0.62) | |
| Lionex | 67.9 (49.3–82.1) | 95.0 (76.4–99.1) | 88.5 (79.5–93.8) | 89.8 (82.2–94.4) | 0.73 (0.63–0.82) | |
| 8–14 days (n = 40) | EDI | 75.0 (59.8–85.8) | 93.8 (79.9–98.3) | 87.2 (78.0–92.9) | 89.1 (81.9–93.7) | 0.75 (0.67–0.84) |
| AnshLabs | 90.0 (77.0–96.0) | 67.9 (54.5–78.9) | 93.0 (83.3–97.2) | 80.9 (72.6–87.2) | 0.61 (0.51–0.72) | |
| Dia.Pro | 72.5 (57.2–83.9) | 93.5 (79.3–98.2) | 86.1 (76.8–92.1) | 88.2 (80.8–93.0) | 0.73 (0.64–0.82) | |
| NovaTec | 87.5 (73.9–94.5) | 77.8 (63.7–87.5) | 92.3 (83.2–96.7) | 86.4 (78.7–91.6) | 0.71 (0.62–0.81) | |
| Lionex | 82.5 (68.1–91.3) | 97.1 (85.1–99.5) | 90.8 (82.2–95.5) | 92.7 (86.3–96.3) | 0.84 (0.77–0.91) | |
| >14 days (n = 33) | EDI | 60.6 (43.7–75.3) | 90.9 (72.2–97.5) | 84.0 (74.5–90.4) | 85.4 (77.4–91.0) | 0.63 (0.53–0.74) |
| AnshLabs | 84.8 (69.1–93.4) | 62.2 (47.6–74.9) | 91.4 (81.4–96.3) | 78.6 (69.8–85.5) | 0.55 (0.44–0.67) | |
| Dia.Pro | 66.7 (49.6–80.3) | 91.7 (74.2–97.7) | 86.1 (76.8–92.1) | 87.4 (79.6–92.5) | 0.69 (0.59–0.79) | |
| NovaTec | 87.9 (72.7–95.2) | 74.4 (58.9–85.4) | 93.8 (85.0–97.5) | 86.4 (78.5–91.7) | 0.70 (0.60–0.80) | |
| Lionex | 87.9 (72.7–95.2) | 96.7 (83.3–99.4) | 94.5 (86.7–97.9) | 95.1 (89.1–97.9) | 0.89 (0.82–0.95) | |
| Overall (n = 101) | EDI | 65.3 (56.1–74.6) | 97.1 (94.5–99.6) | 66.0 (58.9–73.1) | 78.4 (72.2–84.5) | 0.58 (0.46–0.70) |
| AnshLabs | 85.1 (78.2–92.1) | 83.5 (77.9–89.1) | 77.9 (71.7–84.2) | 81.3 (75.4–87.1) | 0.61 (0.49–0.73) | |
| Dia.Pro | 66.3 (57.1–75.6) | 97.1 (94.6–99.6) | 66.7 (59.6–73.7) | 78.9 (72.8–85.1) | 0.59 (0.48–0.71) | |
| NovaTec | 81.2 (73.6–88.8) | 89.1 (84.5–93.8) | 75.9 (69.5–82.4) | 83.0 (77.4–88.7) | 0.66 (0.54–0.77) | |
| Lionex | 80.2 (72.4–88.0) | 98.8 (97.1–100) | 77.5 (71.2–83.8) | 87.7 (82.8–92.6) | 0.76 (0.66–0.85) |