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. 2020 Oct 27;18:169. doi: 10.1186/s12964-020-00660-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — JARID1B inhibited CDX2 expression in CRC cells. a The microarray profiling of gene expression in DLD-1-shJARID1B cells. b, c qRT-PCR and western blot detected CDX2, β-catenin, c-MYC, cyclinD1 expression in DLD-1 cells transfected with shNC or shJARID1B. d, e qRT-PCR and western blot detected CDX2 expression in LOVO cells transfected with vector or Flag-JARID1B. f, h Western blot analysis and qRT-PCR of CDX2 protein levels in CRC tissues and in paired adjacent tissues. g, i Scatter plots showed a negative correlation between JARID1B and CDX2 at the mRNA and protein levels in fresh 54 CRC samples. j Kaplan-Meier analysis for 130 CRC patients follow-up data showed that the prognosis was the poorest for patients with both high JARID1B expression and low CDX2 expression. *p < 0.05, **p < 0.01