Table 2.
Univariate and multivariate analysis of overall survival in CRC patients. (Cox proportional hazards regression model)
| Parameters (130 CRC patients)a | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p value | HR | 95%CI | p value | |
| Age (≦60/> 60) | 0.70 | 0.34–1.41 | 0.32 | |||
| Gender (Male/Female) | 1.13 | 0.57–2.22 | 0.73 | |||
| Histologic grade (well/poor) | 0.66 | 0.29–1.51 | 0.33 | |||
| Tumor size (cm) (< 5/≧5) | 1.78 | 0.90–3.51 | 0.10 | |||
| CEA (ng/ml) (< 5/≧5) | 1.09 | 0.75–1.60 | 0.64 | |||
| Lymphatic invasion (Positive/Negative) | 1.95 | 1.04–3.67 | 0.04* | 1.52 | 0.52–4.43 | 0.03* |
| Distant metastasis (Positive/Negative) | 2.03 | 1.09–3.78 | 0.03* | 1.65 | 0.62–4.38 | 0.01** |
| T classification (T3 + T4/T1 + T2) | 2.65 | 1.20–5.85 | 0.02* | 1.80 | 0.67–4.84 | 0.02* |
| TNM (III, IV/I, II) | 2.49 | 1.24–5.00 | 0.01** | 2.12 | 1.13–3.98 | 0.02* |
| JARID1B protein expression (High/Low) | 2.29 | 1.41–3.73 | 0.00** | 2.53 | 1.50–4.27 | 0.00** |
aImmunohistochemical results of 130 paraffin-embedded tissues from December 2012 to December 2017, *p ≤ 0.05,**p ≤ 0.01