Table 2.
Distribution of the genomic CD177*787A.T variation within the phenotyped blood donors, patients, NIN mothers, and their neonates
| HNA-2 phenotype/HNA-2 immunization |
CD177*
c.787A |
CD177*
c.787A+T |
CD177*
c.787T |
Total |
|---|---|---|---|---|
| Donors | 80 | |||
| HNA-2 negative | 3 | 7 | 32a | 42 |
| Borderline/questionable | 3 | 4 | 2 | 9 |
| ≤40% CD177pos.neutrophils | 3 | 5 | 0 | 8 |
| <40% CD177pos.neutrophils | 21 | 0 | 0 | 21 |
| Patients with HNA-2 alloantibody | 0 | 0 | 3 | 3 |
| NIN mothers with HNA-2 alloantibody | 0 | 1 | 8 | 9 |
| NIN neonates | 4 | 6 | 0 | 10 |
| Fathers of the neonates | 4 | 1 | 0 | 5 |
Values indicate the number of subjects.
a
Three of these had HNA-2 antibody, and the blood product of one was involved in a case of TRALI.