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. 2020 Oct 27;26:96. doi: 10.1186/s10020-020-00226-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Human KBTBD8 was overexpressed in multiple clinical ovarian cancer samples. a KBTBD8 immunohistochemistry on an ovary tissue microarray showed that KBTBD8 level was highly correlated with the malignancy grade of ovarian cancer (Detailed information for each array point is in Additional file 1: Dataset 1). The malignancy grade and corresponding percentage of cells with high-level KBTBD8 are: 0 (0), 1 (60%), 2 (70%), and 3 (100%). b, c Western blot and quantification showed that the KBTBD8 protein level in ovarian cancer tissue was about fourfold higher than in adjacent normal ovarian tissue (Adjacent normal ovarian tissue vs. ovarian cancer tissue, 0.02689 vs. 0.1190). A.U., arbitrary unit. Scale bar, 100 μm. ***Indicates p < 0.001