Table 1.
Baseline characteristics stratified by pre-test probability
| Overall | <5% | 5–15% | >15% | P | |
|---|---|---|---|---|---|
| n | 3755 | 831 | 1302 | 1622 | |
| Female | 1715 (45.7) | 479 (57.6) | 914 (70.2) | 322 (19.9) | <0.001 |
| Age (years) | 57.0 (50.0–64.0) | 47.0 (42.0–51.5) | 56.0 (51.0–61.0) | 63.0 (58.0–68.0) | <0.001 |
| Chest pain type | <0.001 | ||||
| Non-anginal | 1606 (42.8) | 789 (94.9) | 566 (43.5) | 251 (15.5) | |
| Atypical angina | 889 (23.7) | 25 (3.0) | 492 (37.8) | 372 (22.9) | |
| Typical angina | 1260 (33.6) | 17 (2.0) | 244 (18.7) | 999 (61.6) | |
| Hypertension | 1211 (32.5) | 159 (19.3) | 402 (31.2) | 650 (40.3) | <0.001 |
| Hyperlipidaemia | 2078 (55.3) | 299 (36.0) | 662 (50.8) | 1117 (68.9) | <0.001 |
| Diabetes | 370 (9.9) | 58 (7.0) | 123 (9.4) | 189 (11.7) | 0.001 |
| Family history CAD | 1549 (41.7) | 376 (45.7) | 606 (47.1) | 567 (35.2) | <0.001 |
| Smoking history | <0.001 | ||||
| Non-smoker | 770 (20.5) | 253 (30.4) | 276 (21.2) | 241 (14.9) | |
| Ex-smoker | 1177 (31.4) | 193 (23.2) | 369 (28.3) | 615 (38.0) | |
| Current smoker | 1806 (48.1) | 385 (46.3) | 657 (50.5) | 764 (47.2) | |
| Cerebrovascular disease | 123 (3.3) | 13 (1.6) | 35 (2.7) | 75 (4.6) | <0.001 |
| Peripheral vascular disease | 42 (1.1) | 6 (0.7) | 7 (0.5) | 29 (1.8) | 0.003 |
| Systolic blood pressure (mmHg) | 140.0 (125.0–152.0) | 130.0 (120.0–145.0) | 140.0 (125.0–152.0) | 140.0 (130.0–157.0) | <0.001 |
| Diastolic blood pressure (mmHg) | 80.0 (76.0–90.0) | 80.0 (75.0–89.0) | 81.0 (76.0–90.0) | 80.0 (77.0–90.0) | 0.044 |
| Body mass index (kg/m2) | 28.8 (25.6–32.8) | 29.1 (25.2–33.1) | 29.0 (25.6–33.8) | 28.5 (25.8–31.9) | 0.029 |
| Antiplatelet | 1662 (44.3) | 121 (14.6) | 493 (37.9) | 1048 (64.6) | <0.001 |
| Statin | 1459 (38.9) | 103 (12.4) | 405 (31.1) | 951 (58.6) | <0.001 |
| ACE inhibitor | 497 (13.2) | 66 (7.9) | 143 (11.0) | 288 (17.8) | <0.001 |
| Beta-blocker | 786 (20.9) | 57 (6.9) | 215 (16.5) | 514 (31.7) | <0.001 |
CAD, coronary artery disease.