Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Top panel: Dependence of the force acting on the ligand on displacement (left) and time (right). Rupture force Fmax occurs at time tmax. Bottom panel: Displacement dependence of Jarzynski’s binding free energy, showing that the ligand binding/unbinding is a barrier crossing event with the unbinding barrier ΔGunbind‡ and the binding barrier ΔGbind.
