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. 2020 Oct 23;13:10807–10816. doi: 10.2147/OTT.S250369

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© 2020 Wang et al.

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Inhibition of orthotopic tumor growth by miR-16. (A) Formation of orthotopic glioblastoma in nude mouse brains. The site of tumor formation is arrowed. (B) Histology of brain tumors was examined using H&E staining. The size of the tumors was measured and compared. *P<0.05 comparing to CON and NC groups. (C) Immunohistochemistry was done to assess cyclin D1 and WIP1 expression in orthotopic tumors. Magnification 200×. Shown are the representative data sets of three independent experiments.