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. 2020 Oct 23;12:10505–10519. doi: 10.2147/CMAR.S272324

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© 2020 Liu et al.

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Circ_0000260 knockdown alleviated CDDP chemoresistance, thus blocking the malignant behaviors of HGC27/CDDP and AGS/CDDP cells. (A) The difference of cell survival in HGC27/CDDP, AGS/CDDP and their parental cells was monitored using CCK-8 assay with the treatment of different concentrations of CDDP. (B) Cell proliferation of HGC27/CDDP and HGC27 cells after the treatment of CDDP was assessed by CCK-8 assay. (C) The expression of circ_0000260 in HGC27/CDDP, AGS/CDDP and their parental cells was detected by qRT-PCR. (D) The efficiency of siRNA was examined by qRT-PCR. In HGC27/CDDP and AGS/CDDP cells transfected with si-circ#2 or si-NC, (E) cell proliferation was assessed by CCK-8 assay. (F) The ability of colony formation was investigated by colony formation assay. (G) Cell apoptosis was monitored by flow cytometry assay. (H and I) Cell migration and cell invasion were determined by scratch assay and transwell assay, respectively. (J) Cell adhesion capacity was monitored using cell adhesion assay. (K) Cell adhesion-related proteins were quantified by Western blot. **P<0.01, ***P<0.001.