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. 2020 Oct 23;12:10505–10519. doi: 10.2147/CMAR.S272324

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© 2020 Liu et al.

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MiR-129-5p was a target of circ_0000260. (A) The potential miRNAs targeted by circ_0000260 were predicted by circBank and starBase, and then the expression of miR-942-5p, miR-361-3p and miR-129-5p in si-circ#2-transfected cells was detected by qRT-PCR. (B) The expression of miR-129-5p in GAC tumor tissues and adjacent normal tissues was measured by qRT-PCR. (C) The expression correlation between miR-129-5p and circ_0000260 in GAC tissues was analyzed by Spearman correlation analysis. (D) The expression of miR-129-5p in CDDP-resistant or CDDP-sensitive GAC tissues was detected by qRT-PCR. (E) The expression of miR-129-5p in HGC27/CDDP, AGS/CDDP, HGC27 and AGS cells was detected by qRT-PCR. (F) MUT-circ_0000260 sequence was designed according to WT-circ_0000260 sequence to conduct dual-luciferase reporter assay. (G) The interaction between circ_0000260 and miR-129-5p was verified by dual-luciferase reporter assay. (H) The efficiency of circ_0000260 overexpression was examined using qRT-PCR. (I) The expression of miR-129-5p in HGC27/CDDP and AGS/CDDP cells with circ_0000260 overexpression or knockdown was detected by qRT-PCR. *P<0.05, **P<0.01, ***P<0.001.