Table 2.
Pharmacokinetics Data
| Drug | Formulation | GEM/ERL NPs | M-M GEM/ERL NPs | Free GEM/ERL |
|---|---|---|---|---|
| GEM | T1/2 (h) | 8.31 ± 0.92* | 11.51 ± 1.23* | 1.29 ± 0.34 |
| Cmax (L/kg/h) | 23.94 ± 2.13 | 25.17 ± 2.66 | 20.68 ± 1.95 | |
| AUC (mg/L h) | 86.74 ± 3.33* | 106.92 ± 4.64* | 39.45 ± 2.37 | |
| Vd (L/kg) | 3.31 ± 0.51 | 4.12 ± 0.44 | 1.21 ± 0.36 | |
| CL (L/h) | 0.20 ± 0.03 | 0.34 ± 0.05 | 0.65 ± 0.04 | |
| ERL | T1/2 (h) | 9.63 ± 0.86* | 12.41 ± 1.53* | 1.91 ± 0.78 |
| Cmax (L/kg/h) | 17.65 ± 1.83 | 19.32 ± 1.49 | 18.32 ± 1.73 | |
| AUC (mg/L h) | 76.95 ± 4.68* | 113.65 ± 7.14* | 29.53 ± 3.16* | |
| Vd (L/kg) | 3.81 ± 0.41 | 4.98 ± 0.47 | 1.39 ± 0.33 | |
| CL (L/h) | 0.27 ± 0.05 | 0.28 ± 0.04 | 0.50 ± 0.06 |
Notes: Data are presented as Mean ± SD, n = 10; *P < 0.05 by Student’s t-test between M-M GEM/ERL NPs and Free GEM/ERL, or GEM/ERL NPs and Free GEM/ERL.