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. Author manuscript; available in PMC: 2021 Sep 4.
Published in final edited form as: Essays Biochem. 2020 Sep 4;64(2):337–347. doi: 10.1042/EBC20190075

Figure 2. Structural comparison of Cdt1 and SKA1 subunit of the Ska1c.

Figure 2.

Linear and topology diagram of the canonical WTH domains (shown in orange within the grey area). α and β represent α helix and β sheet structures respectively. Note that Cdt1 (to the left, 2A) contain two WTHs: C-terminal WTH (WHC) is shown under the solid box and the middle WTH (WHM) is shown under the dotted box. In addition to the canonical WTH topology possessed by the WHM of Cdt1, the WHC contains one additional α helical component (α4). The single WTH domain of SKA1 (to the right, 2B) has 5 additional helical elements organized as two separate modules (I and II) as indicated. Secondary structural units that are unique to Cdt1 and SKA1 are shown in green.