Table 2. Effects of calculated free testosterone on 439 health outcomes in males from the UK Biobank significant after adjusting for multiple hypothesis testing using Bonferroni correction (p<1.14×10−4).
| Outcome | Effect per 0.1 nmol/L increased CFT (95% CI) |
P-value | Sample Size Cases/Controls |
|---|---|---|---|
| Creatinine | 0.113 SD (0.079 to 0.146) |
4.78 × 10−11 | 149849 |
| C-reactive protein | −0.085 SD (−0.119 to −0.052) |
6.15 × 10−7 | 149547 |
| Spinal stenosis | OR = 2.03 (1.51 to 2.75) |
3.82 × 10−6 | 1917/150919 |
| Apolipoprotein A | −0.018 g/L (−0.026 to −0.01) |
1.55 × 10−5 | 138185 |
| HDL cholesterol | −0.074 SD (−0.109 to −0.039) |
3.62 × 10−5 | 138394 |
| Essential hypertension | OR = 1.17 (1.08 to 1.27) |
7.53 × 10−5 | 40809/115957 |
| Hypertension | OR = 1.17 (1.08 to 1.26) |
1.05 × 10−4 | 40960/115957 |
CFT, calculated free testosterone; HDL, high density lipoprotein; GRS, genetic risk score.