Fig. 2.
Association between DNA-TG and RBC-TGN levels and their relationship with 6-MP dose (mg/day/m2) according to TPMT and NUDT15 variant alleles. (A) Association between DNA-TG and RBC-TGN levels, with regression lines for all 257 measurements at steady state (bold straight solid line) and according to subgroups (light straight solid line for normal metabolizers, stiff-dotted line for NUDT15 intermediate metabolizers, including *1/*2 and *1/*3, and dash-dotted line for measurements in subjects with NUDT15 indeterminate alleles, including *1/*5 and *1/*6). (B) DNA-TG/RBC-TGN ratio by subgroup (C) Association between 6-MP dose and DNA-TG levels. (D) DNA-TG/RBC-TGN ratio with regression line (straight line) and 95% confidence interval (dashed lines) for all results.
Abbreviations: DNA-e-TG, etheno-thioguanine DNA; RBC-TGN, erythrocyte 6-thioguanine nucleotides; 6-MP, mercaptopurine; DNA-TG, DNA-incorporated 6-thioguanine; TPMP, thiopurine S-methyltransferase.