Table 2.

Mean Number of Daily Meals and Dosing Behaviors from Baseline to After Five Health Care Professional Visits

	Baseline level [95% CI]		Visit ≥5 level [95% CI]		Estimated relative change [95% CI]	P
	Daily meals (n)	Proportion of 3 meals	Daily meals (n)	Proportion of 3 meals
MBD	0.74 [0.62; 0.88]	24.7% [20.8; 29.4]	0.42 [0.30; 0.60]	14.1% [9.9; 19.9]	−43.1% [−60.5; −18.0]	0.002
“On-time” dose	0.57 [0.48; 0.69]	19.1% [15.9; 23.0]	0.59 [0.43; 0.80]	19.6% [14.5; 26.7]	2.7% [−24.7; 40.2]	0.865
Undetected mealsa	1.54 [1.37; 1.70]	51.5% [45.6; 56.7]	1.94 [1.69; 2.14]	64.6% [56.4; 71.2]	25.4% [8.7; 43.5]	0.003

Estimated mean data and 95% CI based on a mixed Poisson model, with visit number (baseline, 1, 2, 3, 4, 5+) as fixed effect and participant and visit nested in participant as random effects.

^aAssuming three meals per day on average.

CI, confidence interval; HCP, health care professional; MBD, missed bolus dose; N, number.