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Effects of anti-EGF VacAbs in emergence of resistance to ALK and RET TKIs in ALK and RET translocated cell lines. (A-D) Emergence of resistant colonies to brigatinib, alectinib and crizotinib in H2228 and to BLU667 in LC-2/ad under different conditions. Medium was RPMI+10% FBS, no EGF was added.
