Fig. 1.

8-OaS relieved anxiety-like behaviors in FSS-induced mice. Representative traces in the OFT during a period of 15 min. Behavioral tests were performed on day 14. a, c In the OFT, 8-OaS administration (0.02, 0.2, 2 mg/kg) for 14 days significantly increased b the time spent in the central area but had no effect on c the total distance traveled. In the EPM test, 8-OaS treatment reversed d the number of entries into and e time spent in the open and closed arms. Each value represents the mean ± SEM of three independent experiments (n = 12, *p < 0.05, **p < 0.01 versus the control group; ^#p < 0.05, ^##p < 0.01 versus the FSS group)