Fig. 2.

8-OaS attenuated anxiety-like behaviors in CFA-injected mice. a Representative traces in the OFT during a period of 15 min. Behavioral tests were performed on day 3. b In the OFT, 8-OaS treatment (0.02, 0.2, 2 mg/kg) for 3 days remarkably reversed the time in the center area in CFA-injected mice; however, no difference in c the total distance traveled was observed in either group in the OFT. d In the EPM test, 8-OaS (0.02, 0.2, 2 mg/kg) increased the number of entries into and time spent in the open arms in CFA-injected mice. Each value represents the mean ± SEM of three independent experiments (n = 12, *p < 0.05, **p < 0.01 versus the control group; ^#p < 0.05, ^##p < 0.01 versus the CFA-injected group)