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. 2020 Oct 27;11(10):922. doi: 10.1038/s41419-020-03118-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Lipid ROS accumulation during ferroptosis (0.5 μM ML162) and non-canonical pyroptosis (3 h of 1 µg/ml LPS followed by 8 h incubation after LPS transfection) in the presence of 0.5 µM Fer1. c, d Cell death levels during ferroptosis and non-canonical pyroptosis in the presence of Fer1. e–f Representative fluorescent microscopy images from BMDMs undergoing different modes RCD showing the impact of Fer1 on lipid ROS and cell death. g The impact of Fer1 on ROS production during ferroptosis and non-canonical pyroptosis. h The impact of Fer1 on production of pro-inflammatory cytokines. Heatmaps represent values from three biological replicates. All bars are mean ± SEM of three biological replicates. One-way ANOVA, *p < 0.05, **p < 0.01, p < 0.0001.