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. 2020 Oct 27;11:5426. doi: 10.1038/s41467-020-19197-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Burst pressure (a) and ultimate tensile stress (UTS) (b) of endothelialized TEBVs perfused for 1–4 weeks (mean ± S.D., n = 3 TEBVs, **P = 0.00031, ***P < 0.0001 compared to week 0 without perfusion by one-way ANOVA). c Vasoactivity of endothelialized TEBVs perfused for 1–4 weeks (mean ± S.D., n = 6 TEBVs), Phe: phenylephrine, Ach: acetylcholine. d NO production (total nitrate and nitrite concentration in media) of endothelialized TEBVs perfused for 1–4 weeks (mean ± S.D., n = 2 experiments with 4 TEBV per experiment). e The outer diameter is stable over 4 weeks perfusion, without treatment. Each point represents a value from a single TEBV at each time point. f ECs (endothelial cells) elongate (i) and align (ii) under perfusion (mean ± S.E., n = 44,44,34,45 cells for elongation and n = 134,126,70,77 cells for alignment from 2 TEBVs, ***P < 0.0001 compared to static culture by one-way ANOVA and Tukey post hoc test). g Vasoactivity (i), burst pressure (ii) and UTS (iii) of 2- and 3-layer TEBVs after 1-week perfusion (mean ± S.D., n = 8 for 2-layer-hSMC in (i) and n = 4 for others, P values determined by one-way ANOVA and Tukey post hoc test) (hNDF: human neonatal dermal fibroblasts; hSMC: human smooth muscle cells, Phe: phenylephrine; Ach: acetylcholine).