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. 2020 Oct 27;11:5426. doi: 10.1038/s41467-020-19197-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Perfusion of TEBVs with 50 μg/ml eLDL reduces vasoconstriction and vasodilation, but the response recovers 8 days after removal of eLDL (mean ± S.D., n = 4 TEBVs, *PE: P = 0.01408, Ach: *P = 0.01543 to control by two-way ANOVA and Tukey post hoc test). b Addition of 25 µM NF157 with 50 µg/ml reduces the inhibition of vasoactivity and leads to a more rapid recovery after removal of eLDL (mean ± S.D., n = 4 TEBVs, *P = 0.01369 to control by two-way ANOVA and Tukey post hoc test). c NF157 block eLDL-mediated monocyte accumulation in TEBVs (mean ± S.D., n = 4 TEBVs, *P < 0.05, ***P < 0.0001 to control by two-way ANOVA). d NF157 does not inhibit ICAM-1 and E-selectin expression on endothelial cells in TEBVs (mean ± S.D., n = 3 TEBVs, ICAM-1: *P = 0.0136 control vs. eLDL, *P = 0.0252 control vs. eLDL +NF157; E-selectin *P = 0.0181 control vs. eLDL by two-way ANOVA and Tukey post hoc test, MFI = mean fluorescence intensity; Flow rate: 0.4 Pa to vasoactivity testing and 0.1 Pa for monocyte accumulation).