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. 2020 Oct 27;11:5420. doi: 10.1038/s41467-020-19176-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Peripheral blood was collected in patients DMARD responders (Resp) and DMARD non-responders (Non-Resp) prior to DMARD treatment initiation. Peripheral blood lipid mediator profiles were established in accordance with published criteria including matching retention time and MS/MS fragmentation spectra. Pathway analysis for the differential expression of mediators from the (top panel) DHA and n-3 DPA, and (bottom panel) EPA and AA bioactive metabolomes in Non-Resp when compared to Resp. Statistical differences between the normalised concentrations (expressed as the fold change) of the lipid mediators from the Non-Resp and Resp groups were determined using a two-sided t test followed by a multiple comparison correction using Benjamini–Hochberg procedure. Up- or downregulated mediators are denoted with using upward and downward facing triangles, respectively, and on changes of the node’s size. Bolded mediators represent statistical differences between the two groups when adjusted p value <0.05. Results are representative of n = 66 for Resp and n = 44 Non-Resp. Source data are provided as a Source data file.