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. 2020 Oct 27;10:18316. doi: 10.1038/s41598-020-75529-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CD209a cells are increased in PVPV-Akt1KO mouse thyroid. (A) IHC of CD209a confirmed the presence and increase of expression in PVPV-Akt1KO mouse thyroid by IHC, representative image is shown. (B) Quantitation of four pairs of age-matched PVPV-AktWT and PVPV-Akt1KO mice demonstrate an increase of CD209a cells in the Akt1KO mice (62 ± 27 vs 15 ± 15 cells/20 × field; p < 0.05). (C) The macrophage marker F4/80, was highly expressed in both the PVPV-AktWT and Akt1KO mouse thyroids and the expression pattern was distinct from CD209a. (D) Tg staining was distinct form CD209a staining. (E, F) Confocal microscope images were taken by 40× objective and digitally enlarged by 5× and show a subset of CD209a cells that co-express CD205 (representative images shown). Primary and secondary antibody negative controls are in Supplemental Fig. 4. Graph images were created using Graphpad Prism version 8.4.2 (https://graphad.com).