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. 2020 Oct 27;10:17894. doi: 10.1038/s41598-020-74800-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression profile of Rbm20^S637A/S637A mice is distinct from those of WT and Rbm20^KO/KO mice. Poly(A)⁺ RNAs extracted from ventricles of WT and Rbm20 mutant mice (n = 3 each) were subjected to RNA-seq analysis. (a) Numbers of DEGs between indicated genotypes of mice. A cut-off of a FDR < 0.05 and gene expression fold change > 1.5 or < 0.667 were applied. (b) Enrichment analysis of Rbm20^S637A/S637A vs Rbm20^KO/KO. Bar colors represent p values. (c) A scatter plot for Rbm20^S637A/S637A vs Rbm20^KO/KO. Each dot represents each gene. Skeletal muscle genes and DCM-related genes top-ranked among the DEGs are indicated. (d) Relative expression levels of DEGs between Rbm20^S637A/S637A and Rbm20^KO/KO mice with a GO term ‘muscle system process’ (GO:0003012). Skeletal muscle genes, DCM-related genes, and causative genes of hereditary arrhythmia are colored as indicated. (e) qPCR analysis of DEGs top-ranked in the RNA-seq analysis. n = 3 each. p values with statistical significance after Tukey's HSD test are indicated. Error bars, SEM.