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. 2020 Oct 27;10:18402. doi: 10.1038/s41598-020-75573-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein–protein interaction (PPI), hub IRGs, and functional similarity analysis of DEIRGs. (A) PPI network. The size of a node represents the clustering coefficient, the color indicates the degree, the width of the line indicates the score; the color of the line represents co-expression. (B) Hub IRGs. The hub IRGs were the top 10 DEIRGs scored by the maximum correlation coefficient. (C) Functional similarities of 10 hub IRGs. The boxes indicate the middle 50% of the similarities; the upper and lower boundaries represent the 75th and 25th percentiles. The two ends of the line represent the maximum and minimum values. The dashed line represents the cut-off value of similarity.