Table 2.
IRGs function in the prognostic signature.
| No | Symbol | Full name | Function |
|---|---|---|---|
| 1 | BRAF | B-Raf proto-oncogene, serine/threonine kinase | Associated with progression and poor prognosis of several cancers |
| 2 | CORT | Cortistatin | Biological activities of anti-inflammation, antioxidation, antitumor activity |
| 3 | GAL | Galanin and GMAP prepropeptide | High expression is linked with the initiation and progression of prostate cancer and colorectal cancer |
| 4 | GRN | Granulin precursor | Inhibit the growth of hepatocellular carcinoma |
| 5 | STC2 | Stanniocalcin 2 | High expression is associated with progression and poor outcome of colorectal cancer |
| 6 | TNFRSF11B | TNF receptor superfamily member 11b | High expression is linked with a worse outcome of colorectal cancer |
| 7 | BMP8A | Bone morphogenetic protein 8a | High expression is associated with progression and poor survival of thyroid cancer |
| 8 | PSMD10 | Proteasome 26S subunit, non-ATPase 10 | Abnormal expression is linked with metastasis and worse survival of osteosarcoma |
| 9 | VEGFA | Vascular endothelial growth factor A | Promotes cell proliferation and migration, inhibits apoptosis of osteosarcoma |
| 10 | VAV1 | Vav guanine nucleotide exchange factor 1 | High expression is associated with the prognosis of invasive breast cancer |
| 11 | GNRH1 | Gonadotropin-releasing hormone 1 | Associated with vascular invasion and metastasis of osteosarcoma |
| 12 | SDC3 | Syndecan 3 | Overexpression inhibits the proliferation of mesenchymal tumor cells |
| 13 | TNFRSF21 | TNF receptor superfamily member 21 | Abnormal expression is coupled with growth, migration and invasion of osteosarcoma |