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. 2020 Oct 27;10:18308. doi: 10.1038/s41598-020-75326-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondria-related gene expression in chronically stressed mice and major depression subjects. (A) Enrichment analyses of mitochondria-associated genes encoded by nuclear DNA (nDNA) or mitochondrial DNA (mtDNA) in mCRS and unstressed CTR mice (n = 15/group, PFC; n = 16/group, NAc), chronic variable stress (CVS) mice (PFC: n = 19/group, NAc: n = 20/group) and post-mortem tissue of major depression disorder (MDD; n = 16, ventromedial (vm) PFC; n = 16, NAc) and healthy (CTR; n = 15, vmPFC; n = 17, NAc) subjects. Red, enrichment for up-regulation; blue, enrichment for down-regulation. Data of CVS mice and MDD subjects were reanalyzed from a previously published transcriptome dataset²⁰. (B) Barcode plots for mitochondria-associated genes encoded by nDNA or mtDNA DNA in the PFC of mice exposed to mCRS and of MDD subjects. (C) Gene expression of mtDNA encoded genes in the PFC of mice (p values from generalized linear model). Data are displayed as mean ± SEM. *, p < 0.05, **, p < 0.01, ***, p < 0.001.