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. 2020 Oct 27;10:18300. doi: 10.1038/s41598-020-75171-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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KLF4 influences YFP⁺-derived organoid formation and regenerative capability in response to γ radiation-induced injury. (A, B) Representative images of organoids derived from the FACS-sorted YFP⁺ cells isolated from the Bmi1^Ctrl and Bmi1^∆Klf4 mice at 0, 6, 24, 48, 72, 96, 120, 144 and 168 h after irradiation obtained under a fluorescence microscope. Regenerating organoids are marked by red arrowheads. The lower panel represents fluorescent images, and the upper panel represents merged images of bright-field and fluorescent images. The scale bar represents 500 µm. (C) Quantification of the regeneration rate of organoids derived from the Bmi1^Ctrl and Bmi1^∆Klf4 mice exposed to 6, 8, 10 and 12 Gy γ irradiation. Data are represented as the mean ± SD, n = 4–5 mice per group. *p < 0.05 by one-way ANOVA.