Fig. 1.

HTR2A is overexpressed in human and mouse hypertrophic hearts. a mRNA level of marker genes of hypertrophy in human hearts. The RNAs from control and hypertrophic heart tissues of human patients were used for mRNA analysis with qRT-PCR (n = 6 in each group). ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; β-MHC, myosin heavy chain beta. b mRNA level of HTR2A in human hearts from control donors and patients with cardiac hypertrophy (n = 6 in each group). HTR2A, 5-hydroxytryptamine receptor 2A. c The protein level of HTR2A in human hearts from control donors and patients with cardiac hypertrophy (n = 4 in each group). d mRNA level of marker genes of hypertrophy in mouse hearts. Cardiac hypertrophy was induced in male C57BL/6J mice by chronic treatment of isoproterenol (ISO, 50 mg/kg/day) for 28 days. mRNA levels of hypertrophic marker genes were analyzed with qRT-PCR (n = 5 in each group). e mRNA level of HTR2A in mouse control and hypertrophic hearts (n = 5 in each group). f The protein level of HTR2A in mouse control and hypertrophic hearts (n = 4 in each group). **P < 0.01 analyzed by using the Student’s t test