Fig. 5.

Illustrator showing HRT2A function during cardiac hypertrophy. Upon hypertrophic stress, HTR2A expression is upregulated, which leads to the activation of PI3K. Activated PI3K promotes the activation of AKT in a PDK1-dependent manner. Finally, mTOR and S6K1 signalings are activated by AKT, which results in increased protein synthesis and hypertrophic growth of cardiomyocytes